SYSTEMS BIOLOGY

We seek to understand design principles of biological systems and diseases.

TISSUE DYSREGULATION

We study mechanisms underlying how biological networks rewire during disease progression. Ongoing areas of focus are: cancer drug resistance, neurodegeneration, and ischemia.

TISSUE PATTERNING

We combine intravital imaging, novel organoid systems, computer vision and modeling to understand how complex, patterned tissues develop and are maintained.

SYSTEMS PHARMACOLOGY

We develop rapid, scalable, and effective ways to identify novel drugs and drug targets.

MACHINE LEARNING

We develop computational strategies to understand disease mechanisms and patient populations. Our approaches leverage information across diverse data sources and scales, including molecular (-omics), cellular (high-content microscopy), and physiological (wearable biosensor) data.

DRUG DISCOVERY IN COMPLEX DISEASES

We combine our machine learning strategies with innovative experimental high-throughput approaches to uncover novel targets in diseases of cancer, neurodegeneration, and ischemia.

FUNDING

We are grateful for all the generous support we have received over the years, including current funding from:
The NIH, Project ALS, TargetALS, The Alliance for Therapies in Neuroscience, The Mark Foundation for Cancer Research, and generous gifts from private donors.